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pentobarbital will minimize the level or influence of amlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.pentobarbital will minimize the level or effect of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration. Solid or moderate CYP3A inducers may lo